Background: Life skills training programs help adolescents make healthy choices that lead to meaningful lives. These skills will enhance the youth's mental health and abilities as they face the real challenges of life. It helps young people analyze and take positive action to protect themselves. Life skills facilitate the integrated development of individuals to function effectively. Objective: This review aims to determine the impact of the life skills training program on Psychological well-being (anxiety, depression and stress) among adolescents. Study design and methods: The review will be conducted according to PRISMA guidelines. The International Prospective Register for Systematic Reviews has accepted this protocol. Following the three procedures, a literature search will be conducted on research articles published between 2011 and 2021 that are limited to the English language. A preliminary search will be made using terms such as life skills training, anxiety, depression, stress, and teenagers in the Web of Sciences and PubMed-Medline databases. The titles and abstracts of the studies given will be combed for relevant keywords. The quality of all selected publications will be assessed using the JBI (Joanna Briggs Institute Manual) clinical appraisal checklist for RCTs and non-RCTs. Two authors will independently assess the quality of the work, and any discrepancies will be resolved. Results: A descriptive synthesis will be performed and presented in the form of a narrative summary as tabular format. The summaries will include both narrative descriptions and statistical data from the studies. The meta-analysis will be done for anxiety, depression and stress. Conclusion: This review will help the caretakers (Parents, teachers and mentors etc.,) to acknowledge the importance of incorporating life skills training programs in academics to reach the desired goals of the students. What is already known about the topic? Many studies have successfully concluded the impact of life skills on an individual's well-being, including the following: Haghighi et al. (2006) showed that life skills training enhances adolescent pupils' mental health and self-esteem. Life skills training improves participants' mental health (family stress and social acceptability), according to Samari and Lalifaz (2005). What this paper adds This review aims to determine the impact of the life skills training program on Psychological well-being (anxiety, depression and stress) among adolescents.