Purpose: The proposed study's goal is to identify the consequences and antecedents of employees’ proactive behavior in Pakistan’s health sector. The Job Demands-Resources (JD-R) Theory delves into the workplace environment’s impact on both employee productivity and well-being. This study aims to explore the ramifications of empowering leadership within the framework of the JD-R Theory. Our investigation centers on scrutinizing the interplay between the proactive behavior of employees and empowering leadership, considering the influence of psychological capital as a mediator. Moreover, we endeavor to shed light on the outcomes that materialize when employees exhibit proactive behavior within the context of the healthcare sector. Design/methodology/approach: The research data was gathered from various healthcare facilities through the administration of surveys. To conduct various statistical analyses, we employed SPSS as our primary tool. In order to scrutinize the data comprehensively, regression analysis was conducted with the assistance of SPSS. Additionally, to examine our hypotheses,we employed the SPSS process macro for both Model 1 and Model 4. Findings: In our research, we have discovered a robust and constructive connection between employees' proactive behavior and empowering leadership. Empowering leadership serves as a catalyst, facilitating and nurturing employees' proactive tendencies. This symbiotic relationshipis pivotal for organizations striving to secure a competitive edge in their respective industries. Proactive behavior emerges as a pivotal factor in this equation, as it is directly and positively linked to employees' task performance and their potential for career success. Individuals with a penchant for proactive traits consistently outperform their more passive counterparts. Theirproactivity is marked by behaviors that significantly contribute to the overall success of work-related tasks. In our study, we have identified an intriguing moderator, psychological capital, which exerts a positively influential effect on the relationship between the proactive behavior of employees and empowering leadership. This intriguing moderator acts as a powerful enhancer, furtherfortifying the connection between proactive behavior and empowering leadership. Originality/value: This model will help employees to attain proactive behavior. In the realm of healthcare, the presence of proactive employees holds the key to bestowing a distinctive competitive edge upon organizations within the sector. Their proactive disposition and actions become instrumental in setting them apart from their industry rivals.