Concrete is a material constituted of cement, Sand, Coarse aggregates, and water. Cement is the predominant component of both conventional and Replacement concrete. Cement processing emits massive concentrations of Carbon-dioxide throughout the environment. To reduce the concentration,
cement is substitute by any local available cementitious material. Nowadays, due to the carbon dioxide and global warming, several investigations are undergoing replacement cement. Several new products are used as an effluent substitute medium for cement, like rice husk ash, eggshell residue, baggage ash, etc. Hospital waste management is a huge problem in our society. The annual production of medical waste produced from health care facilities, is around 250,000 tons. The purpose of this study is to determine the feasibility of using hospital waste ash produced from a health care facility as a partial replacement for cement. The quantity of hospital Plastic waste ash (5, 10, 15, and 20% by weight of cement) is the major variable in this study, whereas the amount of cementitious material, water to cementitious material ratio, fine and coarse aggregate content are all constant. Nowadays, there is a need a realistic material like natural sand. Despite the fact that M-sand is used as a substitute for River sand, it comes with a number of drawbacks due to its angular size and inability to fill pore spaces. Silica sand is a silica-containing material that efficiently covers pores in concrete. The primary objective of this research is to partially replace M-Sand with Silica Sand in order to enhance concrete properties. Silica sand is combined with M-Sand in various proportions of 5%, 10%, 15%, and 20%. The tests on fresh and hardened concrete are now complete. The findings show that Silica Sand can be used as a partial substitute for M-Sand.M30 and M45 mix design concrete is used for the experimental investigation. The main important parameters are strength, durability and workability of concrete. The study clearly reveals the investigation into numerous substitutions of cement with hospital plastic waste ash in the mix proportion, 5 % to 20% of its cement weight. The trial mix proportion is carried out for the different properties of workability, durability and strength achieves the optimal level of cement substitution with hospital plastic waste ash.