In today’s era, females are more involved in making independent business decisions related to managing the business. In general, even though the level of entrepreneurship increasing, still, there is only a little research on female graduates towards entrepreneurship, particularly in developing countries. Further, the existing studies have not yet provided considerable attention to female graduates, particularly in hotel management. Thus, a study was presented to analyze the female hotel management graduates’ in pursuing entrepreneurship. By using the methodology of convenience sampling technique, the sample has been collected from 351 female hotel management graduates in Kerala. Measurement modeling was used for the analysis of the hypothesized relationship among constructs. The result showed that the development of attitude and interest in female graduates were associated with considering entrepreneurship as attractive and making them better off financially. It also revealed that the attitude, intention, motivation, and risk-taking mediate the relationship between the entrepreneurial intentions and the career advisor of influencer highly influenced the female graduates towards entrepreneurship.