Background: Artificial Intelligence (AI) is useful in the health sector by contributing to the way in which healthcare is conducted, which is why it seeks to integrate healthcare systems with large-scale data. AI is powered by electronic data and the management of complex data in devices that favors the implementation of interventions. Purpose: To promote the application and knowledge of Artificial Intelligence in the healthcare field as a powerful instrument based on innovative knowledge parallel with modern trends in health and care. Method: A systematic review was conducted by targeting the databases such as Google Scholar, Scopus, Web of Science, Research Gate, Science Direct, ProQuest, Springer, PubMed, Science Direct, JSTOR, Embase, and EBSCO host, ERIC by using Keywords as technology, artificial intelligence, deep learning, technology, health, healthcare, medicine, education, and disease. Only English literature was targeted from 2017 to 2022. Results: Total of 16,022 articles was find out while 15 were selected finally. Findings revealed that AI reflects by various ways of technology and machine-based practices such as mobile applications, computers, internet, and robotic devices. This was also found that such innovations based on AI produced fruitful results in the public health, personal care, medical clinical practices, and pharmacology related fields. As the human errors reduced and work productivity increased. It was found that human resources such as training education, and insight to the use of technology-based devices are also required. To bring improvement still, various challenges and barriers are there in healthcare. This demands the conjunction of these challenges with other social agents to bring improvement in care and health. Conclusions: AI is a great innovation in healthcare. As could bring more fruitful changes according to the modern trends, demands, and requirements as per human dynamics. As human care could be facilitated through the innovative mechanism, information, communication, and technology-based grounds. For this, it is recommended to manage all modern challenges in medicine, public health, and pharmacy through IA.