Background: Working in the clinics usually ponders on the internal as well as external workplace balance that must be free from injustices, inequality, and racism. Nepotism is one of the most effective qualities of working societies that affect the personal perception of the nurses working in hospital and reduces job satisfaction, especially among nurses. Aim of the study: The current study aims to explore the relationship between nurses’ satisfaction and their perception of nepotism practice. Method: A descriptive qualitative method operationalizing the convenient sampling technique to collect the data from staff nurses, nurse managers, and head nurses enrolled in in-patient units (n= 18) and/or out-patients in 3 government hospitals in Saudi Arabia, the interviews were conducted to assess nurses’ satisfaction and perception of nepotism practice in the workplace. Results: The qualitative content analysis was conducted, with 8 themes and 16 subthemes designs. The themes were presented as follows: Misuse of authority, Poor patient care, Culture Issues, Misuse of Nepotism (Wasta), Dissatisfaction, Satisfaction, Reputation, and Discrimination. Themes were divided into sub-themes that demonstrate the in-depth dimensions of each theme. Conclusion: Findings indicate that inequality and nepotism violate society and workplace norms and in return elevate job dissatisfaction among nurses. Solutions include strict administrative policies and procures as well as the rules and regulations by using advanced electronic systems. Reduction of workplace nepotism requires an unbiased, unprejudiced, and fair working committee that works for the appropriate flow of the work like designations, promotions, scholarships, etc.