In the present work, we intended to prosper a convenient method for the synthesis of Thiophene contain novel Pyrazole derivatives (3a-3j) by conventional method with Schiff base and halo acetylation mechanism. All the synthesized moieties were proved on the basis spectral analysis. A sequence of novel Imidazole derivatives is screened for Insilco docking studies and anthelmintic activity. In Anthelmintic activity, among this sequence of compounds 3d, 3e, 3h and 3j showed high activity compare with Albendazole as a standard. Molecular docking analysis were performed in order to locate the viable protein ligand like Beta-tubulin interactions of the dataset ligands (3a-3j). Dock rankings of all the synthesized derivatives ranged from -4.07 (compound 3h) to -3.185 (compound 3j). Compound 3h reported highest dock score of -4.070 with Glide binding energy of -37.743 Kcal/mol.